4-(N-[2,4-二氨基-6-喋啶甲基]-氨基)苯酸钠盐合成路线 （共 14 条）
反应条件
Yield given. Multistep reaction;
参考文献
Nair; Adapa; Bridges
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155
反应条件
1: Ac2O / 2.5 h / Heating 2: 94 percent / Et3N / dimethylformamide / 18 h / 25 °C 3: 74 percent / Et3N / dimethylformamide / 73 h / 55 °C 4: 0.25 N aq. NaOH / 1.75 h / 25 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
sodium hydrogencarbonate in water T=85 - 90°C; 0.25 - 0.333333 h;
参考文献
Rosowsky, Andre; Bader, Henry; Blumbergs, Peter; Lin, Ming-Teh
Patent: US2004/72837 A1, 2004 ;
Location in patent: Page/Page column 8 ;
反应条件
4-(N,N-dimethlyamino)pyridine
T=46°C; 14 h;
参考文献
Wright, Joel E; Rosowsky, Andre
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 493 - 500
