2-(4-苯基苯基)环氧乙烷合成路线 （共 10 条）
反应条件
2,4,6-trimethylpyridine 1-oxide; Ru(VI)(TMP)O2 in benzene T=30°C;
参考文献
Ohtake, Hiro; Higuchi, Tsunehiko; Hirobe, Masaaki
Heterocycles, 1995 , vol. 40, # 2 p. 867 - 904
反应条件
1: With sodium tetrahydroborate in methanol 20 h; 2: With water in methanol
参考文献
ASTRAZENECA AB
Patent: WO2004/20415 A1, 2004 ;
Location in patent: Page 62 ;
WO 2004/020415 A1
反应条件
cesium fluoride in dimethyl sulfoxide 15 h; Ambient temperature;
参考文献
Hioki; Tani; Sato
Synthesis, 1995 , # 6 p. 649 - 650
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in tetrahydrofuran; dimethyl sulfoxide; mineral oil T=20°C; Corey-Corey-Chaykovsky condition; 0.333333 h; Inert atmosphere; 2: biphenyl-4-carboxaldehyde in tetrahydrofuran; dimethyl sulfoxide; mineral oil T=0°C; Corey-Chaykovsky condition; Inert atmosphere;
参考文献
Nielsen, Daniel K.; Doyle, Abigail G.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 27 p. 6056 - 6059
反应条件
sodium tetrahydroborate in methanol 0.5 h; Ambient temperature;
参考文献
Tamura; Takahashi; Shirai; Kawazoe
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1393 - 1400
反应条件
iodosylbenzene; Mn(III)conjugate in chloroform-d1 Yield givenYields of byproduct given;
参考文献
Geier III, G. Richard; Sasaki, Tomikazu
Tetrahedron, 1999 , vol. 55, # 7 p. 1859 - 1870
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium 1.) THF, -70 deg C, 30 min, 2.) THF, -78 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Shi, Li-Lan; Zhou, Zhang-Lin; Huang, Yao-Zeng
Tetrahedron Letters, 1990 , vol. 31, # 29 p. 4173 - 4174
反应条件
sodium methylate 1.) CH3CN; Multistep reaction;
参考文献
Ono; Yamafuji; Chaki; Morita; Todo; Maekawa; Kitamura; Tai; Narita
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 9 p. 1488 - 1491
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; cyclohexyl BrettPhos; water in toluene
T=100°C; Suzuki-Miyaura coupling; 4 h; Inert atmosphere;
参考文献
Nielsen, Daniel K.; Doyle, Abigail G.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 27 p. 6056 - 6059
反应条件
1: 2-(1,1'-biphenyl-4-yl)ethylene oxide With sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane
T=-78°C; 0.00661111 h; flow microreactor;
2: methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-78°C; 0.000555556 h; flow microreactor;
参考文献
Nagaki, Aiichiro; Takizawa, Eiji; Yoshida, Jun-Ichi
Chemistry - A European Journal, 2010 , vol. 16, # 47 p. 14149 - 14158
