环丙炔(4-羟基苯基)甲酮合成路线 （共 10 条）
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=-5 - 0°C; 0.5 h; 2: With phosphoric acid in tetrahydrofuran; water T=-5 - 20°C; 2 h; Reagent/catalystSolventTemperature;
参考文献
Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
反应条件
1: 4-bromobenzyl-alcohol With methyllithium in tetrahydrofuran; diethyl ether T=-78 - 4°C; 0.5 h; 2: With tert.-butyl lithium in tetrahydrofuran; diethyl ether; pentane T=-78°C; 1 h; 3: cyclopropanecarboxylic acid in tetrahydrofuran; diethyl ether; pentane T=0°C;
参考文献
Novo Nordisk A/S
Patent: US6908926 B1, 2005 ;
Location in patent: Page/Page column 42-44 ;
US 6908926 B1
反应条件
sodium hydroxide in water T=20 - 25°C; 0.025 h; Reagent/catalystTemperature;
参考文献
Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
反应条件
2-(N,N-diethylamino)ethanethiol hydrochloride; sodium t-butanolate in N,N-dimethyl-formamide 1 h; Heating;
参考文献
Magano, Javier; Chen, Michael H.; Clark, Jerry D.; Nussbaumer, Thomas
Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7103 - 7105
反应条件
1: With tetrabutylammomium bromide; sodium hydride in N,N-dimethyl-formamide T=20°C; 12 h; 2: With trifluoroacetic acid in dichloromethane T=20°C; 1 h; Further stages.;
参考文献
Grover, Rajesh K.; Mishra, Ram Chandra; Kundu, Bijoy; Tripathi, Rama Pati; Roy, Raja
Tetrahedron Letters, 2004 , vol. 45, # 39 p. 7331 - 7334
反应条件
1.1: AlCl3, aluminium chloride / chlorobenzene / 17 h / 10 - 100 °C 1.2: 2 h / 0 - 20 °C 2.1: hydrogenchloride / water / 9 h / 5 - 100 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -5 - 0 °C 3.2: 2 h / -5 - 20 °C View Scheme
参考文献
Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
反应条件
1.1: hydrogenchloride / water / 9 h / 5 - 100 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -5 - 0 °C 2.2: 2 h / -5 - 20 °C View Scheme
参考文献
Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
反应条件
1.1: AlCl3, aluminium chloride / chlorobenzene / 17 h / 10 - 100 °C 1.2: 2 h / 0 - 20 °C 2.1: hydrogenchloride / water / 9 h / 5 - 100 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -5 - 0 °C 3.2: 2 h / -5 - 20 °C View Scheme
参考文献
Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
反应条件
1: Ph3P; diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 20 °C 2: 2N aq. HCl / acetone / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3987 - 3994
反应条件
toluene-4-sulfonic acid
Heating;
参考文献
Yovell,J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 850 - 855
