6-氨基-4-(3-氯-4氟苯氨基)-7-乙氧基喹啉-3-腈合成路线 （共 23 条）
反应条件
1: 71 percent / aq. H2SO4 / 1 h / 110 - 112 °C 2: 80 percent / toluene / 16 h / Heating 3: 76 percent / Dowtherm / 1.25 h / 256 °C 4: 87 percent / POCl3 / 2.5 h / Heating 5: 95 percent / propan-2-ol / 3.5 h / Heating 6: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 1 p. 49 - 63
反应条件
1: 76 percent / Dowtherm / 1.25 h / 256 °C 2: 87 percent / POCl3 / 2.5 h / Heating 3: 95 percent / propan-2-ol / 3.5 h / Heating 4: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 1 p. 49 - 63
反应条件
1: toluene / 16 h / Heating 2: Dowtherm / 1.25 h / 256 °C 3: 62 percent / TFA anhydride; NH4NO2 4: 87 percent / POCl3 / 2.5 h / Heating 5: 95 percent / propan-2-ol / 3.5 h / Heating 6: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 1 p. 49 - 63
反应条件
hydrogenchloride in water Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 2: pyridine hydrochloride / isopropyl alcohol / Reflux 3: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C 2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C 3: toluene / 90 °C 4: dowtherm A / 250 °C 5: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 6: pyridine hydrochloride / isopropyl alcohol / Reflux 7: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C 2: toluene / 90 °C 3: dowtherm A / 250 °C 4: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 5: pyridine hydrochloride / isopropyl alcohol / Reflux 6: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: acetic acid / 60 °C 2: potassium carbonate / N,N-dimethyl-formamide / 60 °C 3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C 4: toluene / 90 °C 5: dowtherm A / 250 °C 6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 7: pyridine hydrochloride / isopropyl alcohol / Reflux 8: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: toluene / 90 °C 2: dowtherm A / 250 °C 3: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 4: pyridine hydrochloride / isopropyl alcohol / Reflux 5: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: pyridine hydrochloride / isopropyl alcohol / Reflux 2: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
