反应条件
1: p-toluenesulfonic acid / toluene / 18 h / Heating 2: cyclohexane; diethyl ether; toluene / 1) 0 deg C, 0.5 h, 2) r.t., 1.5 h 3: 94 percent / CHCl3 / 360 h / Heating 4: 1) 1-chloroethyl chloroformate, 2) MeOH / 1) 1,2-dichloroethane, a) 0 deg C, 15 min, b) reflux, 2 h, 2) reflux, 4 h 5: 72 percent / K2CO3 / acetonitrile / 48 h / Heating View Scheme
参考文献
Kudzma; Severnak; Benvenga; Ezell; Ossipov; Knight; Rudo; Spencer; Spaulding
Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2534 - 2542
