2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-b]吲哚合成路线 （共 25 条）
反应条件
potassium phosphate in isobutyramide T=100°C; 24 h; Inert atmosphere;
参考文献
MEDIVATION NEUROLOGY, INC.
Patent: WO2009/111540 A1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
hydrogenchloride in ethanol; water T=100°C; 0.5 h;
参考文献
WO2010/67085 A2, ;
Page/Page column 67 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Reflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/125085 A1, 2010 ;
Location in patent: Page/Page column 17-18 ;
US 20100125085 A1
反应条件
acetic acid in water T=20°C; 4 h; Inert atmosphereReflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2529 - 2532
反应条件
1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere 1.2: 1 h / Inert atmosphere 2.1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1: dichloromethane / 20 °C / Inert atmosphere 2: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 3: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 4: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 5: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 2: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 3: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: dichloromethane / 20 °C / Inert atmosphere 3.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 4.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 6.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
