2-(2,6-二氟-3-硝基苯基)乙酸甲酯合成路线 （共 4 条）
反应条件
pyridine in dichloromethane T=20°C;
参考文献
Parlow, John J.; Stevens, Anna M.; Stegeman, Roderick A.; Stallings, William C.; Kurumbail, Ravi G.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4297 - 4312
反应条件
1: 91 percent / HNO3 / methanol / 0.25 h / -10 °C 2: oxalyl chloride; DMF / CH2Cl2 / 20 °C 3: 5.47 g / pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Parlow, John J.; Stevens, Anna M.; Stegeman, Roderick A.; Stallings, William C.; Kurumbail, Ravi G.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4297 - 4312
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 20 °C 2: 5.47 g / pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Parlow, John J.; Stevens, Anna M.; Stegeman, Roderick A.; Stallings, William C.; Kurumbail, Ravi G.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4297 - 4312
反应条件
iron; acetic acid T=80°C;
参考文献
Parlow, John J.; Stevens, Anna M.; Stegeman, Roderick A.; Stallings, William C.; Kurumbail, Ravi G.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4297 - 4312
