3-氯-5-硝基苯甲酸甲酯合成路线 （共 4 条）
反应条件
thionyl chloride T=80°C; 16 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/28789 A1, 2007 ;
Location in patent: Page/Page column 35 ;
反应条件
durch Austausch von NH2 gegen Chlor nach der Sandmeyerschen Methode;
参考文献
Journal of the Chemical Society, , vol. 87, p. 1271
反应条件
tin(ll) chloride in 1,4-dioxane T=70°C; 2 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/28789 A1, 2007 ;
Location in patent: Page/Page column 35 ;
反应条件
1: With diisobutylaluminium hydride in toluene
T=-78 - 10°C; 1 h;
2: With hydrogenchloride; water in toluene
T=0°C;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/144127 A1, 2007 ;
Location in patent: Page/Page column 38 ;
WO 2007/144127 A1
