3-(1-甲基-3,4-二氢-2-萘)-吡啶合成路线 （共 6 条）
反应条件
hydrogenchloride T=100°C; 2 h;
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1.1: NaNH2 / dimethylformamide / 2 h / 20 - 80 °C 1.2: 47 percent / dimethylformamide / 4 h / 20 - 80 °C 2.1: 74 percent / aq. NaOH / ethanol / 24 h / Heating 3.1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C 4.1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating 5.1: 63 percent / aq. HCl / 2 h / 100 °C View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating 2: 63 percent / aq. HCl / 2 h / 100 °C View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C 2: 41 percent / tetrahydrofuran; toluene / 3 h / Heating 3: 63 percent / aq. HCl / 2 h / 100 °C View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 74 percent / aq. NaOH / ethanol / 24 h / Heating 2: 90 percent / polyphosphoric acid / 0.33 h / 110 °C 3: 41 percent / tetrahydrofuran; toluene / 3 h / Heating 4: 63 percent / aq. HCl / 2 h / 100 °C View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1.1: NaNH2 / dimethylformamide / 2 h / 20 - 80 °C 1.2: 47 percent / dimethylformamide / 4 h / 20 - 80 °C 2.1: 74 percent / aq. NaOH / ethanol / 24 h / Heating 3.1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C 4.1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating 5.1: 63 percent / aq. HCl / 2 h / 100 °C View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
