(3S,5S)-二氢-5-[(1S,3S)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基-1-(苄胺基)戊基]-3-异丙基-2(3H)-呋喃酮合成路线 （共 13 条）
反应条件
copper diacetate; zinc in water; acetic acid T=20°C; 55 h;
参考文献
Speedel Pharma AG
Patent: EP1215201 A2, 2002 ;
Location in patent: Page 12 ;
反应条件
1: 94 percent / H2 / Pd/C / ethanol / 18 h 2: ethanol / 1.5 h / 0 °C 3: 24 mg / NaBH4 / ethanol / 0.67 h / 20 °C View Scheme
参考文献
Lindsay, Karl B.; Skrydstrup, Troels
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4766 - 4777
反应条件
1: With sodium tetrahydroborate in methanol 1 h; 2: With hydrogenchloride in methanol; water 3: With sodium hydroxide in water pH=11; Product distribution / selectivity;
参考文献
DSM IP ASSETS BV; VRIES DE, Andreas, Hendrikus, Maria; VERZIJL, Gerardus, Karel, Maria; HERMSEN, Petrus, Johannes; CASTELIJNS, Anna, Maria, Cornelia, Francisca
Patent: WO2010/10165 A1, 2010 ;
Location in patent: Page/Page column 39 ;
