(5-溴吡啶-3-基)氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
diphenylphosphoranyl azide; triethylamine in toluene T=65 - 100°C; Curtius rearrangement;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4535 - 4546
反应条件
1: 5 -Bromo -pyridin-3 -ylamine With sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.333333 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 24 h;
参考文献
WO2011/28741 A1, ;
Page/Page column 247-248 ;
WO 2011/028741 A1
反应条件
1: 3-bromo-5-pyridine-carboxylic acid With diphenyl phosphoryl azide; triethylamine in 1,4-dioxane T=20°C; 0.5 h; 2: tert-butyl alcohol in 1,4-dioxane T=75°C;
参考文献
US2007/149534 A1, ;
Page/Page column 24 ;
反应条件
anhydrous sodium hydrogen carbonate; diphenylphosphoranyl azide; triethylamine in dichloromethane; tert-butyl alcohol
参考文献
EP1264820 A1, ;
EP 1264820 A1
反应条件
cBRIDP; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate in water T=50°C; 24 h; Inert atmosphereGreen chemistry;
参考文献
Green Chemistry, , vol. 16, # 3 p. 1480 - 1488
反应条件
N,N-dimethylethylenediamine; sodium iodide; copper(l) iodide in 1,4-dioxane T=110°C; 24 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/60970 A1, 2005 ;
Location in patent: Page/Page column 150 ;
WO 2005/060970 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 20 h; Inert atmosphereSealed tube;
参考文献
PETER MACCALLUM CANCER INSTITUTE; SPICER, Julie Ann; DENNY, William Alexander; MILLER, Christian Karl; O'CONNOR, Patrick David; HUTTUNEN, Kristiina; TRAPANI, Joseph A.; HILL, Geoff; ALEXANDER, Kylie
Patent: WO2014/28968 A1, 2014 ;
Location in patent: Page/Page column 102 ;
