benzene T=160°C;

water T=100°C; unter Druck;

(i) aq. HCO2H, HCl, (ii) /BRN= 3589311/; Multistep reaction;

1: N,N-Dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride in water T=30 - 35°C; 8.3 h; Large scale; 2: diethyl ((4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazoline-6-ylcarbamoyl)methyl)phosphonate With lithium chloride; potassium hydroxide in water T=-7 - -5°C; 2 h; Large scale;

1: N,N-Dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride in water T=20 - 30°C; Inert atmosphere; 2: Diethyl {[4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetrahydrofuran-3-Yloxy)-Quinazolin-6-Ylcarbamoyl]-Methyl}-Phosphonate With lithium chloride; potassium hydroxide in tetrahydrofuran T=-15 - 20°C; 2.5 h; Inert atmosphere; Product distribution / selectivity;

1: N,N-Dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride; water T=0 - 40°C; Inert atmosphere; 2: diethyl 2-[4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-ylamino]-2-oxoethylphosphonate With sodium ethanolate; lithium chloride in ethanol; water T=-20°C; 3 h;

暂无反应条件数据

in cyclohexanone

in acetic acid 6 h; Heating;