反-4-羟基环己烷甲酸乙酯合成路线 （共 30 条）
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere 2: acetic acid; sodium hypochlorite / 1 h / 20 °C View Scheme
参考文献
Wauters, Iris; De Blieck, Ann; Muylaert, Koen; Heugebaert, Thomas S. A.; Stevens, Christian V.
European Journal of Organic Chemistry, 2014 , vol. 2014, # 6 p. 1296 - 1304
反应条件
NH4VO3; nitric acid; copper
参考文献
Henkel and Cie.
Patent: DE957940 , 1956 ;
反应条件
carbonylchlorohydridetris(triphenylphosphine) ruthenium(II); ammonia; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,1-dimethylpropan-1-ol T=130°C; P=9750.98 Torr; 20 h; Inert atmosphereAutoclave; chemoselective reaction;
参考文献
Imm, Sebastian; Baehn, Sebastian; Zhang, Min; Neubert, Lorenz; Neumann, Helfried; Klasovsky, Florian; Pfeffer, Jan; Haas, Thomas; Beller, Matthias
Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7599 - 7603
反应条件
1: 100 percent / 8 N Jones reagent / acetone 2: 80 percent / NaOH / ethanol / 5 h / 20 °C 3: 80 percent / POCl3 / pyridine / 4 h / 20 °C View Scheme
参考文献
Kimura; Diwan; Yanagi; Kon-No; Nojima
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 3 p. 407 - 410
反应条件
1: 83 percent / PCC; neutral alumina / CHCl3 / 3 h 2: 95 percent / NaOH / methanol; H2O / 3 h View Scheme
参考文献
Kimura; Diwan; Yanagi; Kon-No; Nojima
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 3 p. 407 - 410
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph
Patent: US2014/121198 A1, 2014 ;
Location in patent: Paragraph 0897; 0898 ;
反应条件
1: silver oxide 2: ethanol; sodium View Scheme
参考文献
Owen; Robins
Journal of the Chemical Society, 1949 , p. 326,331
参考文献
Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1576 - 1586
参考文献
Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1576 - 1586
反应条件
1: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h 2: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 8 p. 2110 - 2114
