反-4-羟基环己烷甲酸乙酯合成路线 （共 30 条）
反应条件
1: chromic acid 2: 93 percent / p-toluene sulfonic acid 3: 1.) Ph3CLi / 1) cooling (ice-bath), 45 min, THF, hexane; 2) THF, hexane, cooling (ice-bath), 90 min 4: 50W-X4(H+), water / ethanol / 1 h / Heating 5: dichlorodicyanoquinone / 23 h / Heating View Scheme
参考文献
Pettit, George R.; Harvey, Thomas B.
Synthetic Communications, 1981 , vol. 11, # 3 p. 167 - 178
反应条件
jones reagent in acetone Jones oxidation;
参考文献
Biological and Pharmaceutical Bulletin, , vol. 18, # 3 p. 407 - 410
反应条件
in ethyl acetate; acetonitrile
参考文献
US6586446 B1, ;
US 6586446 B1
反应条件
1: chromic acid 2: 93 percent / p-toluene sulfonic acid View Scheme
参考文献
Pettit, George R.; Harvey, Thomas B.
Synthetic Communications, 1981 , vol. 11, # 3 p. 167 - 178
反应条件
1: 14.8 percent / Et3N / dimethylformamide / Ambient temperature 2: 6.7 percent / diethylaminosulfur trifluoride / CH2Cl2 / 2 h / Ambient temperature 3: 77 percent / TFA / 0.03 h View Scheme
参考文献
Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1576 - 1586
反应条件
ethanol; copper oxide-chromium oxide
T=250°C; P=154457 Torr; Hydrogenation;
参考文献
Owen; Robins
Journal of the Chemical Society, 1949 , p. 326,331
反应条件
T=250°C; P=154457 Torr; Hydrogenation;
参考文献
Owen; Robins
Journal of the Chemical Society, 1949 , p. 326,331
反应条件
1: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h
2: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
3: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 95 percent / pyridine / 24 h / Ambient temperature
5: 72 percent / LiBr / tetrahydrofuran / 36 h / Heating
6: Bu3SnH / 1 h / Irradiation
View Scheme
参考文献
Della, Ernest W.; Knill, Andrew M.; Pigou, Paul E.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2110 - 2114
反应条件
1: aqueous HCl / Erwaermen des Reaktionsprodukts mit SOCl2
2: diphenyl cadmium
View Scheme
参考文献
Stevens; Farkas
Journal of the American Chemical Society, 1953 , vol. 75, p. 3306
