N-乙酰-L-苯丙氨酸甲酯合成路线 （共 84 条）
反应条件
Carica papaya lipase in hexane T=45°C; Resolution of racemateEnzymatic reaction;
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
stannous bromide; triethylamine in dichloromethane T=20°C; Substitution; 9 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Li, Wen-Ren; Yo, Ying-Chih; Lin, Yu-Sheng
Tetrahedron, 2000 , vol. 56, # 45 p. 8867 - 8875
反应条件
in benzene T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 26 p. 3310 - 3312
反应条件
1: SOCl2 / 24 h / 20 °C 2: 3 g / pyridine / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 51, # 17 p. 4866 - 4872
反应条件
hydrogen; lt;phenyl 4,6-O-benzylidene-2,3-bis-O-lt;bislt;3,5-(trimethylsilyl)phenylgt;phosphinogt;-β-D-glucopyranosidegt;Rh(COD)gt;+SbF6- 1.) THF, room temperature, 30 psi, 16 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 6012 - 6025
反应条件
1: AlCl3; N,N-dimethylaniline / CH2Cl2 / 4 h / Heating 2: Na2CO3 / CH2Cl2; H2O / 2 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4437 - 4441
反应条件
hydrogen; lt;methyl 4,6-di-O-benzylidene-3,4-bis-O-lt;bis(3,5-dimethylphenyl)phosphinogt;-α-D-glucopyranosidegt;Rh(COD)gt;+SbF6- 1.) THF, room temperature, 30-40 psi, 3 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 6012 - 6025
反应条件
1: (Wang resin)-C6H4-CH2O-(p-C6H4CH2O)-CO-L-Phe-OMe With trifluoroacetic acid in dichloromethane Solid phase reaction; Hydrolysis; 2: acetic anhydride With triethylamine in dichloromethane Acetylation;
参考文献
Tetrahedron, , vol. 56, # 45 p. 8867 - 8875
反应条件
1: 83 percent / aq. NaOH / 6 h / Heating 2: SOCl2 / 24 h / 20 °C 3: 3 g / pyridine / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 51, # 17 p. 4866 - 4872
反应条件
1: tetrahydrofuran / 0.25 h / 0 °C 2: 1.) NaH / 1.) THF, 2.) 0 deg C, 30 min 3: 0.4 N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 19 p. 2295 - 2298
