2-氨基-1-(4-苄基-1-哌嗪)-乙酮双盐酸盐合成路线 （共 5 条）
反应条件
hydrazine hydrate in ethanol 0.5 h; Heating;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.81 Torr; 3 h;
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Preti, Delia; Cruz-Lopez, Olga; Tabrizi, Mojgan Aghazadeh; Moorman, Allan R.; Gessi, Stefania; Fogli, Eleonora; Sacchetto, Valeria; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3706 - 3715
反应条件
1: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 17 h / 20 °C 2: H2 / Pd/C / ethanol / 3 h / 2585.81 Torr View Scheme
参考文献
Lee, Kyungae; Ren, Tao; Coite, Marceline; Gholamreza, Berahman; Misasi, John; Bruchez, Anna; Cunningham, James
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 239 - 243
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 6 h; Inert atmosphere;
参考文献
Lee, Kyungae; Ren, Tao; Coite, Marceline; Gholamreza, Berahman; Misasi, John; Bruchez, Anna; Cunningham, James
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 239 - 243
反应条件
1: 95 percent / dimethylformamide / 5 h / 20 °C 2: 98 percent / NH2NH2*H2O / ethanol / 0.5 h / Heating View Scheme
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
