2’,3’邻异亚丙基尿苷合成路线 （共 52 条）
反应条件
1: CF3COOH (90percent) 2: 79 percent / (C6H5O)2CO / dimethylformamide View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1956 , p. 2388,2392
Journal of the Chemical Society, 1958 , p. 3028,3032
反应条件
1: HN3, ADDP, Me3P 2: H+ 3: H2 / Rh/C View Scheme
参考文献
Falck; Mekonnen, Belew; Yu, Jurong; Lai, Jing-Yu
Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 6096 - 6097
反应条件
pyridine; trichlorophosphate T=-35 - -30°C; anschl. Erwaermen mit wss. H2SO4;
参考文献
Michelson; Todd
Journal of the Chemical Society, 1949 , p. 2476,2484
Full Text Show Details
Hall; Khorana
Journal of the American Chemical Society, 1954 , vol. 76, p. 5056,5058
反应条件
indium trifluoromethanesulfonate in water; acetonitrile T=120°C; 0.0833333 h; Microwave irradiation;
参考文献
Golden, Kathryn C.; Gregg, Brian T.; Quinn, John F.
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4010 - 4013
反应条件
1: 31 percent / KOH / H2O / 48 h / 60 °C 2: AcOH / H2O / 5 h / Heating View Scheme
参考文献
Gavriliu; Fossey; Fontaine; Benzaria; Ciurea; Delbederi; Lelong; Laduree; Aubertin; Kirn
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 5-6 p. 1017 - 1031
反应条件
1: pyridine; chlorophosphoric acid dibenzyl ester / -40 - -30 °C / anschl. Hydrierung 2: aqueous H3PO4; aqueous pyridine View Scheme
参考文献
Hall; Khorana
Journal of the American Chemical Society, 1954 , vol. 76, p. 5056,5058
反应条件
1: pyridine; chlorophosphoric acid dibenzyl ester / -40 - -30 °C / anschl. Hydrierung 2: aqueous H3PO4; aqueous pyridine View Scheme
参考文献
Kenner et al.
Journal of the Chemical Society, 1952 , p. 3675,3678
反应条件
triethylamine in dichloromethane 0.0833333 h; Ambient temperature;
参考文献
Danishefsky; DeNinno; Chen; Boisvert; Barbachyn
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5810 - 5818
反应条件
1.1: 96 percent / imidazole / CH2Cl2 / 0 - 20 °C 2.1: LDA / tetrahydrofuran / 1 h / -78 °C 2.2: 68 percent / iodine / tetrahydrofuran / -78 °C 3.1: 86 percent / aq. TFA / 0 - 20 °C View Scheme
参考文献
Bello, Angelica M.; Poduch, Ewa; Fujihashi, Masahiro; Amani, Merhnaz; Li, Yan; Crandall, Ian; Hui, Raymond; Lee, Ping I.; Kain, Kevin C.; Pai, Emil F.; Kotra, Lakshmi P.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 5 p. 915 - 921
反应条件
1: CF3COOH (90percent) 2: 79 percent / (C6H5O)2CO / dimethylformamide 3: 61 percent / LiOH View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1956 , p. 2388,2392
Journal of the Chemical Society, 1958 , p. 3028,3032
