2’,3’邻异亚丙基尿苷合成路线 （共 52 条）
反应条件
1: 76 percent / pyridine / 2 h / Ambient temperature 2: 1) Silver acetate / 1) pyridine, room temperature, 15 min 2) 20 deg C 3: 20percent formic acid / 2 h / 40 °C View Scheme
参考文献
Agrawal, Sudhir; Misra, Krishna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 132 - 134
反应条件
1: 83 percent / Ph3P/CCl4 / dimethylformamide / 16 h / 20 °C 2: 80 percent / (n-Bu)3SnH/α,α'-azobisisobutyronitrile / toluene / 2 h / Heating 3: 86 percent / Dowex-50x8 (H-form) / H2O / 2 h / Heating View Scheme
参考文献
Mikhailov, S. N.; Grishko, N. B.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , vol. 24, p. 75 - 78
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 1 p. 91 - 94
反应条件
trifluoromethyl hypofluorite; triethylamine 1.) CCl3F; 2.) MeOH, H2O; Yield given. Multistep reaction;
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: CF3COOH (90percent) 2: N,N-dimethylaminopyridine View Scheme
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: pyridine
2: aqueous acetic acid
3: pyridine
4: methanol. NH3
View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1956 , p. 2388,2392
Journal of the Chemical Society, 1958 , p. 3028,3032
反应条件
1: HN3, ADDP, Me3P
2: H+
3: H2 / Rh/C
4: 76 percent / dimethylformamide / 3 h / 23 °C
View Scheme
参考文献
Falck; Mekonnen, Belew; Yu, Jurong; Lai, Jing-Yu
Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 6096 - 6097
反应条件
1.1: 31 percent / KOH / H2O / 48 h / 60 °C
2.1: AcOH / H2O / 5 h / Heating
3.1: 169 mg / imidazole; DMAP / dimethylformamide / 2 h
4.1: NaOH / dimethylsulfoxide; H2O / 0.33 h / 20 °C
4.2: 41 percent / dimethylsulfoxide; H2O / 1.5 h
5.1: 77 percent / AIBN; Bu3SnH / toluene / 3 h / Heating
6.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
View Scheme
参考文献
Chung, Raymond; Anderson, Karen S.
Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8361 - 8363
反应条件
1: H2O / 1 h / Heating
2: acetonitrile / 0.25 h / Heating
3: 66 percent / Raney nickel / ethanol / 1.5 h / Heating
4: 86 percent / aq. formic acid / 1 h / Ambient temperature
View Scheme
参考文献
Jones, Simon S.; Reese, Colin B.; Ubasawa, Aiko
Synthesis, 1982 , # 4 p. 259 - 260
反应条件
sodium hydrogencarbonate; lithium chloride in acetonitrile
Ambient temperatureelectrolysis (Pt electrodes, SCE reference, LiClO4 as supporting electrolyte);
参考文献
Palmisano, G.; Danieli, B.; Santagostino, M.; Vodopivec, B.; Fiori, G.
Tetrahedron Letters, 1992 , vol. 33, # 50 p. 7779 - 7782
反应条件
1: 2',3'-O-isopropylideneuridine; N-chlorocarbonyl isocyanate in tetrahydrofuran
T=-20 - 0°C; 2 h; Inert atmosphereMolecular sieve;
2: 1-aminotetraacetoglucose With triethylamine in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Toth, Marietta; Somsak, Laszlo
Carbohydrate Research, 2010 , vol. 345, # 1 p. 163 - 167
