3-(4-氟苯基)-3-苯丙酸合成路线 （共 10 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=3750.38 Torr; 24 h;
参考文献
Ghorai, Prasanta; Kraus, Anja; Keller, Max; Goette, Carsten; Igel, Patrick; Schneider, Erich; Schnell, David; Bernhardt, Guenther; Dove, Stefan; Zabel, Manfred; Elz, Sigurd; Seifert, Roland; Buschauer, Armin
Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7193 - 7204
反应条件
1: piperidine / toluene / 0.5 h / Heating 2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min 3: aq. H2SO4, CH3COOH / 24 h / Heating View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: Behandeln des Reaktionsprodukts mit kalter wss. Na2CO3 2: ethanol; palladium/barium sulfate / Hydrogenation View Scheme
参考文献
Bergmann et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1612,1614
反应条件
1.1: NaH; NaI / dimethylformamide 1.2: dimethylformamide / 38 h / 60 - 90 °C 2.1: aq. KOH / ethanol / 12 h / Heating 3.1: 0.17 h / 180 °C View Scheme
参考文献
Elz, Sigurd; Kramer, Kai; Leschke, Christian; Schunack, Walter
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 41 - 52
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min 2: aq. H2SO4, CH3COOH / 24 h / Heating View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
BTISA; trifluorormethanesulfonic acid T=16 - 20°C; Friedel-Crafts bimolecular cyclization; Inert atmosphere;
参考文献
Posternak, Anna G.; Garlyauskayte, Romute Yu.; Yagupolskii, Lev M.
Journal of Fluorine Chemistry, 2010 , vol. 131, # 2 p. 274 - 277
反应条件
1: NaOAc, Ac2O 2: Na-Hg, aq. NaOH View Scheme
参考文献
Shotter,R.G. et al.
Tetrahedron, 1978 , vol. 34, p. 741 - 746
反应条件
1: aq. NaOH 2: NaOAc, Ac2O 3: Na-Hg, aq. NaOH View Scheme
参考文献
Shotter,R.G. et al.
Tetrahedron, 1978 , vol. 34, p. 741 - 746
反应条件
aluminium trichloride
参考文献
Dippy; Young
Journal of the Chemical Society, 1952 , p. 1817,1821
反应条件
PPA; Polyphosphoric acid (PPA)
T=100°C; 3 h;
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
