3-氨基-n-甲基吡嗪-2-羧酰胺合成路线 （共 3 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2008/115369 A2, 2008 ;
Location in patent: Page/Page column 132-133 ;
WO 2008/115369 A2
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran; ethanol T=50°C;
参考文献
Naito, Youichiro; Akahoshi, Fumihiko; Takeda, Shinji; Okada, Takehiro; Kajii, Masahiko; Nishimura, Hiroko; Sugiura, Masanori; Fukaya, Chikara; Kagitani, Yoshio
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 3019 - 3029
参考文献
Albert et al.
Journal of the Chemical Society, 1952 , p. 4219,4220
