1,3-苯并噻唑-6-羧酸合成路线 （共 14 条）
反应条件
1: in methanol; dichloromethane
T=0 - 20°C;
2: With acetic acid in methanol; dichloromethane
0.5 h;
参考文献
Roche Palo Alto LLC
Patent: US2006/40927 A1, 2006 ;
Location in patent: Page/Page column 38 ;
US 20060040927 A1
反应条件
in tetrahydrofuran
T=0 - 20°C; 1 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2009/75778 A2, 2009 ;
Location in patent: Page/Page column 49-50 ;
反应条件
thionyl chloride
2 h; Heating / reflux;
参考文献
Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz
Patent: US2005/209274 A1, 2005 ;
Location in patent: Page/Page column 35-36 ;
US 20050209274 A1
反应条件
1: SOCl2
View Scheme
参考文献
Fridman
Zhurnal Obshchei Khimii, 1950 , vol. 20, p. 1191,1195; engl. Ausg. S. 1235, 1239
