acetic acid in tetrahydrofuran; water T=40°C; 20 h;

1.1: 100 percent / HCl / 3 h / Heating 2.1: LDA / tetrahydrofuran / 0.5 h / -60 °C 2.2: tetrahydrofuran / 1 h / -60 - 20 °C 3.1: LiOH / methanol; H2O / 20 h / 20 °C 4.1: 57percent MCPBA / CHCl3 / 3 h / Heating 5.1: imidazole / dimethylformamide / 12 h / 20 °C 6.1: LDA / tetrahydrofuran / 2 h / -60 °C 6.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 7.1: MCPBA / CHCl3 / 2 h / 20 °C 8.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme

1.1: LDA / tetrahydrofuran / 0.5 h / -60 °C 1.2: tetrahydrofuran / 1 h / -60 - 20 °C 2.1: LiOH / methanol; H2O / 20 h / 20 °C 3.1: 57percent MCPBA / CHCl3 / 3 h / Heating 4.1: imidazole / dimethylformamide / 12 h / 20 °C 5.1: LDA / tetrahydrofuran / 2 h / -60 °C 5.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 6.1: MCPBA / CHCl3 / 2 h / 20 °C 7.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme

1.1: 57percent MCPBA / CHCl3 / 3 h / Heating 2.1: imidazole / dimethylformamide / 12 h / 20 °C 3.1: LDA / tetrahydrofuran / 2 h / -60 °C 3.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 4.1: MCPBA / CHCl3 / 2 h / 20 °C 5.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme

1.1: LiOH / methanol; H2O / 20 h / 20 °C 2.1: 57percent MCPBA / CHCl3 / 3 h / Heating 3.1: imidazole / dimethylformamide / 12 h / 20 °C 4.1: LDA / tetrahydrofuran / 2 h / -60 °C 4.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 5.1: MCPBA / CHCl3 / 2 h / 20 °C 6.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme

1.1: imidazole / dimethylformamide / 12 h / 20 °C 2.1: LDA / tetrahydrofuran / 2 h / -60 °C 2.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 3.1: MCPBA / CHCl3 / 2 h / 20 °C 4.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme

1.1: LDA / tetrahydrofuran / 2 h / -60 °C 1.2: tetrahydrofuran / 0.5 h / -60 - 20 °C 2.1: MCPBA / CHCl3 / 2 h / 20 °C 3.1: AcOH / H2O; tetrahydrofuran / 20 h / 40 °C View Scheme