(8R,9S,13S,14S,17S)-13-乙基-3-甲氧基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-17-醇合成路线 （共 14 条）
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3625-82-9(8R,9S,13S,14S,17S)-13-乙基-3-甲氧基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-17-醇
反应条件
(i) succinic anhydride, Py, (ii) (racemate resolution using (+)-amphetamine), (iii) aq. NaOH, EtOH; Multistep reaction;
参考文献
Buzby Jr.; Hartley; Hughes; Smith; Gadsby; Jansen
Journal of medicinal chemistry, 1967 , vol. 10, # 2 p. 199 - 204
3625-82-9(8R,9S,13S,14S,17S)-13-乙基-3-甲氧基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-17-醇
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反应条件
tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide in dichloromethane 0.5 h; Ambient temperature;
参考文献
Rao, Pemmaraju N.; Cessac, James W.; Kim, Hyun K.
Steroids, 1994 , vol. 59, # 11 p. 621 - 627
反应条件
in water; isopropyl alcohol; acetone
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: US2003/83377 A1, 2003 ;
3625-82-9(8R,9S,13S,14S,17S)-13-乙基-3-甲氧基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-17-醇
→
反应条件
1: CrO3, aq. H2SO4 / acetone 2: Py, aq. HCl / 180 °C View Scheme
参考文献
Rufer,C. et al.
Justus Liebigs Annalen der Chemie, 1971 , vol. 752, p. 1 - 13
