3-溴-4-氰基苯甲酸乙酯合成路线 （共 5 条）
反应条件
1: With tert.-butylnitrite; boron trifluoride diethyl etherate in dichloromethane T=-10 - 20°C; 4 h; 2: With sodium cyanide; copper (I) cyanide in toluene T=0 - 60°C; 1.5 h;
参考文献
US2005/282825 A1, ;
Page/Page column 8 ;
US 20050282825 A1
反应条件
1: 4-amino-3-methoxy-benzoic acid ethyl ester With tert.-butylnitrite; boron trifluoride diethyl etherate in dichloromethane 2: copper (I) cyanide With sodium cyanide in water; toluene
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 153 - 158
反应条件
1.1: 38 percent / Br2; pyridine / CH2Cl2 / 24 h / -10 - 20 °C 2.1: BF3*Et2O; t-BuONO / CH2Cl2 2.2: 48 percent / NaCN / toluene; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 153 - 158
反应条件
diisobutylaluminium hydride in dichloromethane
T=-100°C;
参考文献
Wang, Gary T.; Wang, Xilu; Wang, Weibo; Hasvold, Lisa A.; Sullivan, Gerry; Hutchins, Charles W.; O'Conner, Steve; Gentiles, Robert; Sowin, Thomas; Cohen, Jerry; Gu, Wen-Zhen; Zhang, Haiying; Rosenberg, Saul H.; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 153 - 158
反应条件
1: With sodium hydroxide; ethanol; water in tetrahydrofuran
20 h;
2: With hydrogenchloride in tetrahydrofuran; ethanol; water
参考文献
Wyeth
Patent: US2005/282825 A1, 2005 ;
Location in patent: Page/Page column 8 ;
US 20050282825 A1
