乙基8-(4-联苯基)-8-氧代辛酸酯合成路线 （共 4 条）
反应条件
1: 7-iodo-heptanoic acid ethyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc 2: With lithium chloride in tetrahydrofuran 3: biphenyl-4-carbonyl chloride in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 283 - 287
参考文献
Delorme, Daniel; Woo, Soon Hyung; Vaisburg, Arkadii
Patent: US2002/115826 A1, 2002 ;
反应条件
1.1: 83 percent / NaI / acetone / Heating 2.1: Zn; (CH2)Br2; TMSCl / tetrahydrofuran / 16 h / 20 - 60 °C 2.2: CuCN; LiCl / tetrahydrofuran / 0.17 h / 0 °C 2.3: tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 13 p. 2877 - 2885
参考文献
Delorme, Daniel; Woo, Soon Hyung; Vaisburg, Arkadii
Patent: US2002/115826 A1, 2002 ;
