3,5-二氟-4-甲氧基苯胺合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
反应条件
1: 96 percent / HNO3 / acetic acid / 15 - 20 °C 2: 94 percent / K2CO3 / acetone / 6 h / Heating 3: 99 percent / H2 / 10 percent Pd/C / ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 2 p. 329 - 332
反应条件
1: 94 percent / K2CO3 / acetone / 6 h / Heating 2: 99 percent / H2 / 10 percent Pd/C / ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 2 p. 329 - 332
反应条件
1: fuming HNO3, conc. H2SO4 2: 91 percent / ammonium formate, 10percent Pd/C / methanol / 0.67 h / 21 °C View Scheme
参考文献
Journal of Pharmacy and Pharmacology, , vol. 45, # 8 p. 736 - 744
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
alkaline sodium hypobromite
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
1: thionyl chloride; diethyl ether; ammonia 2: aqueous alkaline sodium hypobromite View Scheme
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
1: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck 2: concentrated H2SO4; HNO3 3: platinum; methanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
1: platinum / Hydrogenation 2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck 3: concentrated H2SO4; HNO3 4: platinum; methanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
1: ethanolic KOH-solution 2: thionyl chloride; diethyl ether; ammonia 3: aqueous alkaline sodium hypobromite View Scheme
参考文献
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
