(E)-3-(2,2-二甲基-[1,3]二氧杂烷-4-基)-丙烯酸乙酯合成路线 （共 25 条）
反应条件
1.1: DBU / methanol / 18 h / 20 °C 2.1: MeOH / 3 h / 0 - 5 °C 2.2: aq. H2SO4 / methanol / 0 - 5 °C 3.1: LiBH4 / tetrahydrofuran / 2.5 h / 50 °C 3.2: 76 percent / aq. HCl / tetrahydrofuran / 2 h / -10 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 26 p. 5917 - 5920
反应条件
1: 60 percent / 30percent H2SO4 / methanol / 0.5 h / Ambient temperature
2: 40 percent / pyridine / CH2Cl2 / 24 h / 0 °C
View Scheme
参考文献
Haefele, Brigitte; Jaeger, Volker
Liebigs Annalen der Chemie, 1987 , p. 85 - 88
反应条件
sulfuric acid in methanol
0.5 h; Ambient temperature;
参考文献
Haefele, Brigitte; Jaeger, Volker
Liebigs Annalen der Chemie, 1987 , p. 85 - 88
反应条件
1.1: DBU / methanol / 18 h / 20 °C
2.1: MeOH / 3 h / 0 - 5 °C
2.2: aq. H2SO4 / methanol / 0 - 5 °C
View Scheme
参考文献
Quaedflieg, Peter J. L. M.; Kesteleyn, Bart R. R.; Wigerinck, Piet B. T. P.; Goyvaerts, Nicolaas M. F.; Vijn, Robert Jan; Liebregts, Constantinus S. M.; Kooistra, Jaap H. M. H.; Cusan, Claudia
Organic Letters, 2005 , vol. 7, # 26 p. 5917 - 5920
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-20°C; 3 h; Title compound not separated from byproducts;
参考文献
Schomaker, Jennifer M.; Pulgam, Veera Reddy; Borhan, Babak
Journal of the American Chemical Society, 2004 , vol. 126, # 42 p. 13600 - 13601
