1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.75 h / -78 °C 1.2: -78 - 20 °C 2.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0 - 20 °C 2.2: 2.25 h / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 0 - 20 °C / Inert atmosphere 4.1: Reflux 5.1: palladium 10 on activated carbon; hydrogen / methanol / 3102.97 Torr 6.1: magnesium / diethyl ether / Inert atmosphere; Reflux 6.2: 20 °C 7.1: potassium carbonate; thiophenol / 1-methyl-pyrrolidin-2-one / 0.5 h / 220 - 230 °C / Inert atmosphere View Scheme

1: 90 percent / MnO2 / CHCl3 / 0.17 h 2: 98 percent / p-TsOH*H2O / toluene / 1.5 h / Heating 3: 1.) O2, Rose Bengal, 2.) thiourea / 1.) CH3OH, CH2Cl2, 12 deg C, irradiation, 30 min, 2.) CH3OH, CH2Cl2, 12 h 4: 90 percent / H2 / 10percent Pd/C / ethanol / 1 h 5: 56 mg / BBr3 / CHCl3 / 1 h / 0 °C 6: 6 N aq. H2SO4 / 12 h / Heating View Scheme

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.75 h / -78 °C 1.2: -78 - 20 °C 2.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0 - 20 °C 2.2: 2.25 h / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 0 - 20 °C / Inert atmosphere 4.1: Reflux 5.1: magnesium / diethyl ether / Inert atmosphere; Reflux 5.2: 1 h / 20 °C / Inert atmosphere 6.1: potassium carbonate; thiophenol / 1-methyl-pyrrolidin-2-one / 0.5 h / 220 - 230 °C / Inert atmosphere View Scheme