3-(4-氟苯基)-5-吡啶羧酸合成路线 （共 8 条）
反应条件
1: 3-bromo-5-pyridine-carboxylic acid With benzotriazol-1-ol; Wang resin; diisopropyl-carbodiimide in N,N-dimethyl-formamide 2: 4-fluorophenyl boronic acid With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; Suzuki coupling reaction; 24 h; 3: With trifluoroacetic acid in dichloromethane 0.333333 h;
参考文献
Tetrahedron Letters, , vol. 46, # 4 p. 581 - 585
反应条件
sodium hydroxide in water
反应条件
water; lithium hydroxide hydrate in 1,4-dioxane T=23°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 22 p. 6812 - 6815
反应条件
di-tert-butyl dicarbonate; hydrogen; palladium diacetate; triphenylphosphine in tetrahydrofuran T=100°C; P=67506.8 - 82508.3 Torr; 24 h; Product distribution / selectivity;
参考文献
WO2005/123682 A1, ;
Page/Page column 8 ;
反应条件
hydrogen; trimethylacetic anhydride; palladium diacetate; triphenylphosphine in tetrahydrofuran T=100°C; P=75007.5 Torr; 20 h; Product distribution / selectivity;
参考文献
WO2005/123682 A1, ;
Page/Page column 5-6 ;
反应条件
hydrogen; trimethylacetic anhydride; palladium diacetate; triphenylphosphine in tetrahydrofuran
T=100°C; P=75007.5 Torr; 20 h; Product distribution / selectivity;
参考文献
MERCK PATENT GMBH
Patent: WO2005/123682 A1, 2005 ;
Location in patent: Page/Page column 5-6 ;
