(R)-(+)-甲基丁二酸合成路线 （共 39 条）
反应条件
hydrogen; [(R)-BINAP]RuBr2 T=50°C; P=2250.2 Torr;
参考文献
Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre
Journal of Organometallic Chemistry, 1998 , vol. 567, # 1-2 p. 163 - 171
反应条件
hydrogen; triethylamine; Ru2Cl4((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2 in tetrahydrofuran; toluene T=35°C; P=2206.5 Torr; 24 h; op = 88percent, var. cat.; RuHCl*<(+)-BINAP>2; Title compound not separated from byproducts;
参考文献
Yamashita, Mitsuji; Kobayashi, Mineaki; Sugiura, Motoyuki; Tsunekawa, Kenji; Oshikawa, Tatsuo; et al.
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 1 p. 175 - 178
反应条件
hydrogen; chiral iridium phosphorothioite on silica in dichloromethane T=40°C; P=15001.5 Torr; Title compound not separated from byproducts.;
参考文献
Journal of Catalysis, , vol. 254, # 1 p. 91 - 100
反应条件
potassium hydroxide in 1,4-dioxane; water 12 h; Heating;
参考文献
Bajwa, Joginder S.; Miller, Marvin J.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1114 - 1116
反应条件
hydrogen; triethylamine; lt;Rh(cod)lt;2S,4S-2-(CH2-PPh2)-4-PPh2-pyrrolidine-1-COOtBugt;BF4 in methanol; benzene T=20°C; P=15200 Torr; 20 h; effects of added Et3N on stereoselectivity; Product distributionMechanism;
参考文献
Journal of Organic Chemistry, , vol. 45, # 23 p. 4728 - 4739
反应条件
sodium hydroxide in methanol; tert-butyl alcohol 24 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 119, # 28 p. 6496 - 6511
反应条件
Tris-HCl buffer; NADH-H+ T=30°C; pH=7.5; 48 h;
参考文献
Angewandte Chemie - International Edition, , vol. 46, # 21 p. 3934 - 3937
反应条件
1: With sodium hydroxide; water T=0 - 20°C; pH=10.67; 16.16 h; 2: With hydrogenchloride; sodium hydrogensulfite in water T=25°C; pH=0.11; 3: With acetic anhydride in toluene T=75°C; 0.583333 h; Product distribution / selectivity;
参考文献
WO2007/10387 A2, ;
Page/Page column 43 ;
反应条件
1: With ozone in methanol T=-78°C; 2: With formic acid; dihydrogen peroxide in methanol 30 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 16, # 11 p. 2007 - 2013
反应条件
1.1: 96 percent / Et3N / CH2Cl2 / 1 h / 0 °C 2.1: [Rh2{(S)-N-phthaloyl-tert-leucinate}4] / toluene / 1 h / -78 °C 3.1: O3 / methanol / -78 °C 3.2: H2O2; formic acid / methanol / 30 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 11 p. 2007 - 2013
