(R)-(+)-甲基丁二酸合成路线 （共 39 条）
反应条件
1.1: [Rh2{(S)-N-phthaloyl-tert-leucinate}4] / toluene / 1 h / -78 °C 2.1: O3 / methanol / -78 °C 2.2: H2O2; formic acid / methanol / 30 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 11 p. 2007 - 2013
反应条件
1.1: 91 percent / p-acetamidobenzenesulfonyl azide; Et3N / acetonitrile / 3 h / 20 °C 2.1: 96 percent / Et3N / CH2Cl2 / 1 h / 0 °C 3.1: [Rh2{(S)-N-phthaloyl-tert-leucinate}4] / toluene / 1 h / -78 °C 4.1: O3 / methanol / -78 °C 4.2: H2O2; formic acid / methanol / 30 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 11 p. 2007 - 2013
反应条件
oxygen in water T=30°C; Saccharomycopsis lipolytica SQL349;
参考文献
Chemistry Letters, , # 5 p. 785 - 786
反应条件
formic acid; (bppm)Rh(1,1,1,5,5,5,-hexafluoroacetylacetonate); triethylamine in dimethylsulfoxide-d6 T=30°C; 0.166667 h; Title compound not separated from byproducts.;
参考文献
Dalton Transactions, , # 5 p. 752 - 758
反应条件
1: 1.) (CH3)3SiCl, 2.) 10percent NaHCO3, 3.) 6 N HCl / 1.) acetonitrile, reflux, 24 h 2: 88 percent / 20percent KOH (aqueous) / dioxane; H2O / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 7 p. 1114 - 1116
反应条件
hydrogenchloride in water T=105°C;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 22 p. 5470 - 5474
反应条件
1: aq. NaOH / methanol / 1 h / Heating 2: aq. HCl / 5 h / Heating View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 10 p. 2535 - 2546
反应条件
sodium hydroxide in ethanol 4 h; Heating;
参考文献
Mueller, Andre; Keller-Schierlein, Walter; Bielecki, Jacek; Rak, Gabriele; Stuempfel, Joachim; Zaehner, Hans
Helvetica Chimica Acta, 1986 , vol. 69, p. 1829 - 1832
反应条件
hydrogen; lt;Rhlt;(2S,3S)-2,3-o-bis(diphenylphosphino)-N-phenyltartimidegt;Clgt;2 P=41800 Torr; 17 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organometallic Chemistry, , vol. 229, # 1 p. 77 - 84
反应条件
1: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; acetonitrile; water / 1 h / 20 °C 2: sulfuric acid / 1,4-dioxane / 12 h / 0 °C / |Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 614 - 627
