7-[[(2E)-3-(4,5-二氢-5,5-二甲基-4-氧代-2-呋喃基)-2-丁烯-1-基]氧基]-2H-1-苯并吡喃-2-酮合成路线 （共 59 条）
反应条件
1.1: 72 percent / H2 / Pd/C / methanol / 16 h / 1551.44 Torr 2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C 2.2: 70 percent / tetrahydrofuran; heptane; ethylbenzene / -78 °C 3.1: Et3N; MeSO2Cl / tetrahydrofuran / 20 °C View Scheme
参考文献
Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Viola, Giampietro; Vedaldi, Daniela; Dall'Acqua, Francesco
Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7473 - 7476
反应条件
1: 34 percent / TiCl4 / CH2Cl2 / 1 h / 0 °C 2: 76 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / Heating 3: 80 percent / K2CO3, LiI / 18-crown-6 / acetone / 16 h / Heating View Scheme
参考文献
Sakai, Takashi; Ito, Hiroshi; Yamawaki, Akitoshi; Takeda, Akira
Tetrahedron Letters, 1984 , vol. 25, # 28 p. 2987 - 2988
反应条件
1: 72 percent / DMAP, p-toluenesulfonyl chloride / CH2Cl2 / 3 h / Ambient temperature 2: 93.2 percent / K2CO3, KI / dimethylformamide; benzene / 3 h / 85 °C 3: 91.7 percent / acetic acid / H2O / 0.5 h / Heating 4: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 9 h / Heating View Scheme
参考文献
Chen, Kau-Ming; Joullie, Madeleine M.
Tetrahedron Letters, 1984 , vol. 25, # 4 p. 393 - 394
反应条件
1: 100 percent / diisobutylaluminum hydride / CH2Cl2 / 2 h / -78 °C 2: 72 percent / DMAP, p-toluenesulfonyl chloride / CH2Cl2 / 3 h / Ambient temperature 3: 93.2 percent / K2CO3, KI / dimethylformamide; benzene / 3 h / 85 °C 4: 91.7 percent / acetic acid / H2O / 0.5 h / Heating 5: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 9 h / Heating View Scheme
参考文献
Chen, Kau-Ming; Joullie, Madeleine M.
Tetrahedron Letters, 1984 , vol. 25, # 4 p. 393 - 394
反应条件
1: 30 percent 2: 92 percent / molibdenumhexacarbonyl / acetonitrile; H2O / 1.5 h / Heating 3: 95 percent / 75 percent acetic acid / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Jackson, Richard F. W.; Raphael, Ralph A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 535 - 539
反应条件
1: 91 percent / MCPBA, sodium bicarbonate / CH2Cl2; H2O / 0 °C 2: 1.) selenium dioxide; 2.) PCC, molecular sieve 4A / 1.) camphorsulfonic acid / 1.) dioxane, 50 deg C; 2.) CH2Cl2, RT View Scheme
参考文献
Kang, S. H.; Hong, C. Y.
Tetrahedron Letters, 1987 , vol. 28, # 6 p. 675 - 678
反应条件
1: 50 percent 2: 76 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / Heating 3: 80 percent / K2CO3, LiI / 18-crown-6 / acetone / 16 h / Heating View Scheme
参考文献
Sakai, Takashi; Ito, Hiroshi; Yamawaki, Akitoshi; Takeda, Akira
Tetrahedron Letters, 1984 , vol. 25, # 28 p. 2987 - 2988
反应条件
1: 76 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / Heating 2: 80 percent / K2CO3, LiI / 18-crown-6 / acetone / 16 h / Heating View Scheme
参考文献
Sakai, Takashi; Ito, Hiroshi; Yamawaki, Akitoshi; Takeda, Akira
Tetrahedron Letters, 1984 , vol. 25, # 28 p. 2987 - 2988
反应条件
1: 93.2 percent / K2CO3, KI / dimethylformamide; benzene / 3 h / 85 °C 2: 91.7 percent / acetic acid / H2O / 0.5 h / Heating 3: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 9 h / Heating View Scheme
参考文献
Chen, Kau-Ming; Joullie, Madeleine M.
Tetrahedron Letters, 1984 , vol. 25, # 4 p. 393 - 394
反应条件
1: 91.7 percent / acetic acid / H2O / 0.5 h / Heating 2: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 9 h / Heating View Scheme
参考文献
Chen, Kau-Ming; Joullie, Madeleine M.
Tetrahedron Letters, 1984 , vol. 25, # 4 p. 393 - 394
