7-[[(2E)-3-(4,5-二氢-5,5-二甲基-4-氧代-2-呋喃基)-2-丁烯-1-基]氧基]-2H-1-苯并吡喃-2-酮合成路线 （共 59 条）
反应条件
1: 20 percent / selenium dioxide, camphorsulfonic acid / dioxane / 1.5 h / 55 °C 2: 80 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 12 h / Ambient temperature 3: DDQ / dioxane / Heating View Scheme
参考文献
Baraldi; Manfredini; Simoni; Tabrizi; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1877 - 1882
反应条件
1: 71 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2; H2O / 3 h / 0 °C 2: 20 percent / selenium dioxide, camphorsulfonic acid / dioxane / 1.5 h / 55 °C 3: 80 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 12 h / Ambient temperature 4: DDQ / dioxane / Heating View Scheme
参考文献
Baraldi; Manfredini; Simoni; Tabrizi; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1877 - 1882
反应条件
1: NaH / dimethylformamide 2: 71 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2; H2O / 3 h / 0 °C 3: 20 percent / selenium dioxide, camphorsulfonic acid / dioxane / 1.5 h / 55 °C 4: 80 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 12 h / Ambient temperature 5: DDQ / dioxane / Heating View Scheme
参考文献
Baraldi; Manfredini; Simoni; Tabrizi; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1877 - 1882
反应条件
1: 80 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 12 h / Ambient temperature 2: DDQ / dioxane / Heating View Scheme
参考文献
Baraldi; Manfredini; Simoni; Tabrizi; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1877 - 1882
反应条件
1: 96 percent / K2CO3 / acetone / 16 h / Heating 2: 55 percent / Et3N, copper(I) iodide / (Ph3P)2PdCl2 / CH2Cl2 / 6 h 3: 98 percent / CH2Cl2 / 16 h 4: 22 percent / oxalic acid / tetrahydrofuran; H2O / 0.75 h View Scheme
参考文献
Jackson, Richard F. W.; Raphael, Ralph A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 535 - 539
反应条件
1: 91.5 percent / K2CO3, KI / dimethylformamide; benzene / 3 h / 85 °C 2: 91.7 percent / acetic acid / H2O / 0.5 h / Heating 3: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 9 h / Heating View Scheme
参考文献
Chen, Kau-Ming; Semple, J. Edward; Joullie, Madeleine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 3997 - 4005
反应条件
1: 85 percent / triethylamine, phenylisocyanate / benzene / Ambient temperature 2: 93 percent / lithium hydroxyde monohydrate / methanol; H2O / 0.17 h / 0 °C 3: 1.) triethylamine; 2.) 2 percent citric acid; / CH2Cl2 / 0.5 h / Ambient temperature 4: potassium carbonate, lithium bromide / acetone / 0.5 h / Heating 5: 92 percent / molibdenumhexacarbonyl / acetonitrile; H2O / 1.5 h / Heating 6: 95 percent / 75 percent acetic acid / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Baraldi; Barco; Benetti; et al.
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5319 - 5322
反应条件
1: 1.) triethylamine; 2.) 2 percent citric acid; / CH2Cl2 / 0.5 h / Ambient temperature 2: potassium carbonate, lithium bromide / acetone / 0.5 h / Heating 3: 92 percent / molibdenumhexacarbonyl / acetonitrile; H2O / 1.5 h / Heating 4: 95 percent / 75 percent acetic acid / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Baraldi; Barco; Benetti; et al.
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5319 - 5322
反应条件
1: 93 percent / lithium hydroxyde monohydrate / methanol; H2O / 0.17 h / 0 °C 2: 1.) triethylamine; 2.) 2 percent citric acid; / CH2Cl2 / 0.5 h / Ambient temperature 3: potassium carbonate, lithium bromide / acetone / 0.5 h / Heating 4: 92 percent / molibdenumhexacarbonyl / acetonitrile; H2O / 1.5 h / Heating 5: 95 percent / 75 percent acetic acid / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Baraldi; Barco; Benetti; et al.
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5319 - 5322
反应条件
1: 92 percent / molibdenumhexacarbonyl / acetonitrile; H2O / 1.5 h / Heating 2: 95 percent / 75 percent acetic acid / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Baraldi; Barco; Benetti; et al.
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5319 - 5322
