7-[[(2E)-3-(4,5-二氢-5,5-二甲基-4-氧代-2-呋喃基)-2-丁烯-1-基]氧基]-2H-1-苯并吡喃-2-酮合成路线 （共 59 条）
反应条件
1: 95 percent / Et3N / CH2Cl2 / 1.) 0 deg C, 5 min, 2.) 0 deg C -> room temperature, 15 min 2: 95 percent / K2CO3, LiBr / acetone / 2.5 h / Heating View Scheme
参考文献
Jackson; Raphael
Tetrahedron Letters, 1983 , vol. 24, # 20 p. 2117 - 2120
反应条件
1: hexane / 16 h 2: AcOH / H2O / 0.67 h / Heating 3: 95 percent / Et3N / CH2Cl2 / 1.) 0 deg C, 5 min, 2.) 0 deg C -> room temperature, 15 min 4: 95 percent / K2CO3, LiBr / acetone / 2.5 h / Heating View Scheme
参考文献
Jackson; Raphael
Tetrahedron Letters, 1983 , vol. 24, # 20 p. 2117 - 2120
反应条件
1: 76 percent / triethylamine / dimethylformamide / 18 h / Ambient temperature 2: n-butyllitium, diisopropylamine 3: 41 percent / chromium trioxide, pyridine / CH2Cl2 / 3 h / Ambient temperature 4: 41 percent / 10percent HCl, / H2O; tetrahydrofuran / Ambient temperature 5: diisopropylamine, n-butyllithium / THF, -78 deg C 6: dicyclohexylcarbodiimide, cuprous chloride / benzene / 26 h / Heating View Scheme
参考文献
Jerris, Paula J.; Smith, Amos B.
Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 577 - 585
反应条件
1: 41 percent / 10percent HCl, / H2O; tetrahydrofuran / Ambient temperature 2: diisopropylamine, n-butyllithium / THF, -78 deg C 3: dicyclohexylcarbodiimide, cuprous chloride / benzene / 26 h / Heating View Scheme
参考文献
Jerris, Paula J.; Smith, Amos B.
Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 577 - 585
反应条件
1: 76 percent / sodium periodate / H2O; dioxane / 40 h / Ambient temperature 2: diisopropylamine, n-butyllithium / THF, -78 deg C 3: dicyclohexylcarbodiimide, cuprous chloride / benzene / 26 h / Heating View Scheme
参考文献
Jerris, Paula J.; Smith, Amos B.
Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 577 - 585
反应条件
oxalic acid in tetrahydrofuran; water 0.75 h;
参考文献
Jackson, Richard F. W.; Raphael, Ralph A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 535 - 539
反应条件
1: 1.) selenium dioxide; 2.) PCC, molecular sieve 4A / 1.) camphorsulfonic acid / 1.) dioxane, 50 deg C; 2.) CH2Cl2, RT View Scheme
参考文献
Kang, S. H.; Hong, C. Y.
Tetrahedron Letters, 1987 , vol. 28, # 6 p. 675 - 678
反应条件
1: 2.) PCC oxidation, molecular sieve 4A / 1.) p-toluenesulfonic acid / 1.) benzene, reflux; 2.) CH2Cl2, RT View Scheme
参考文献
Kang, S. H.; Hong, C. Y.
Tetrahedron Letters, 1987 , vol. 28, # 6 p. 675 - 678
反应条件
1: LiBr 2: molibdenum hexacarbonyl / acetonitrile; H2O / Heating 3: 96 percent / AcOH / 4 h / 0 °C View Scheme
参考文献
Baraldi; Barco; Benetti; et al.
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5319 - 5322
反应条件
1: aq. AcOH 2: 95 percent / Et3N / CH2Cl2 / 0 °C 3: 95 percent / K2CO3, LiBr / acetone / Heating View Scheme
参考文献
Jackson, Richard F. W.; Raphael, Ralph A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 535 - 539
