N-(3-氯丙基)二丁基胺合成路线 （共 12 条）
反应条件
thionyl chloride in chloroform; water; dimethyl sulfoxide
反应条件
thionyl chloride; chloroform
参考文献
Journal of the American Chemical Society, , vol. 67, p. 1416,1417
Journal of the American Chemical Society, , vol. 63, p. 2435
参考文献
Journal of the American Chemical Society, , vol. 67, p. 735,737
Journal of the American Chemical Society, , vol. 68, p. 1542
CH221596 , ;
Helvetica Chimica Acta, Engi-Festschr.<1941>215
反应条件
1.1: potassium carbonate / butanone / 0.5 h / 20 °C 1.2: 12 h / 78 - 82 °C 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 25 - 35 °C 3.1: triethylamine / dichloromethane / 0.5 h / 20 °C 3.2: 1.5 h / 20 °C View Scheme
参考文献
LABORATORIOS LESVI, S.L.; VISHNU NEWADKAR, Ravindranath; CHANGDEO GAIKWAD, Avinash; MADHUKAR HARAD, Ajay
Patent: WO2012/52448 A1, 2012 ;
反应条件
1.1: potassium carbonate / butanone / 0.5 h / 20 °C 1.2: 12 h / 78 - 82 °C 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 25 - 35 °C 3.1: triethylamine / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
GLENMARK GENERICS LIMITED; SRIVASTAVA, Sachin; CRASTO, Anthony Melvin; GHARPURE, Milind; DEORE, Dinesh Bansilal; NARAYANAN, Suresh Babu
Patent: WO2012/7959 A1, 2012 ;
反应条件
1.1: potassium carbonate / butanone / 0.5 h / 20 °C 1.2: 12 h / 78 - 82 °C 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 25 - 35 °C View Scheme
反应条件
1: 2-n-butyl 3-(4-hydroxy benzoyl)-5-nitro benzofuran With potassium carbonate in acetonitrile 0.5 h; 2: 1-chloro-3-(di-n-butylamino)-propane in acetonitrile Reflux;
参考文献
USV Limited, B.S.D. Marg
Patent: US2012/108828 A1, 2012 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: potassium carbonate / butanone / |Reflux 2: sodium methylate / 1-methyl-pyrrolidin-2-one / 5 - 20 °C 3: acetic acid / 12 h / 20 °C 4: acetic acid / 6 h / 117 °C View Scheme
参考文献
SANOFI; BAILLY, Frederic; BON, Xavier; VAYRON, Philippe
Patent: US2013/165674 A1, 2013 ;
反应条件
2: Raney nickel; methanol.ammonia / 78 °C / 25742.8 Torr / Hydrogenation View Scheme
参考文献
Archer; Suter
Journal of the American Chemical Society, 1952 , vol. 74, p. 4296,4301
参考文献
Blicke; Kaplan
Journal of the American Chemical Society, 1943 , vol. 65, p. 1967,1968
