((1R,2S)-2-氨基环己基)氨基甲酸叔丁酯合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=1654.92 Torr; 4 h;
参考文献
ASTRAZENECA AB
Patent: US2007/287695 A1, 2007 ;
Location in patent: Page/Page column 14; 56 ;
US 20070287695 A1
反应条件
1: 97.9 percent / pyridine; DMAP / 0 °C 2: 87 percent / NaN3 / dimethylformamide / 12 h / 65 - 70 °C 3: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
反应条件
1: 87 percent / NaN3 / dimethylformamide / 12 h / 65 - 70 °C 2: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
反应条件
hydrazine hydrate in ethanol 2 h; Reflux;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
反应条件
1: ethyl acetate 2: 98 percent / DMAP; pyridine / 5 h / 0 - 5 °C 3: 87 percent / NaN3 / dimethylformamide / 18 h / 72 °C 4: H2 / PtO2 / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 17 p. 3013 - 3016
反应条件
1: ethyl acetate 2: 98 percent / DMAP; pyridine / 5 h / 0 - 5 °C 3: 87 percent / NaN3 / dimethylformamide / 18 h / 72 °C 4: H2 / PtO2 / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 17 p. 3013 - 3016
反应条件
1: NaOMe / methanol / 0.5 h / 20 °C 2: ethyl acetate 3: 98 percent / DMAP; pyridine / 5 h / 0 - 5 °C 4: 87 percent / NaN3 / dimethylformamide / 18 h / 72 °C 5: H2 / PtO2 / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 17 p. 3013 - 3016
反应条件
1: 92.6 percent / H2 / PtO2 / ethyl acetate / 3 h / 20 °C / 1810.02 - 2068.59 Torr 2: 97.9 percent / pyridine; DMAP / 0 °C 3: 87 percent / NaN3 / dimethylformamide / 12 h / 65 - 70 °C 4: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
反应条件
1: NaN3; NH4Cl / aq. ethanol / 18 h / Heating 2: pyridine; DMAP / 16 h / 20 °C 3: lipase Amano-PS; aq. phosphate buffer / 2.5 h / pH 7.2 4: 92.6 percent / H2 / PtO2 / ethyl acetate / 3 h / 20 °C / 1810.02 - 2068.59 Torr 5: 97.9 percent / pyridine; DMAP / 0 °C 6: 87 percent / NaN3 / dimethylformamide / 12 h / 65 - 70 °C 7: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
