DL-3-氨基-3-苯基丙酸合成路线 （共 124 条）
反应条件
hydrogenchloride 1 h; Heating; Yield given;
参考文献
Kuehne, Paul; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1085 - 1094
反应条件
hydrogenchloride; sodium nitrite inactive β-oxy-β-phenyl-propionic acid;
参考文献
Posner
Chemische Berichte, 1905 , vol. 38, p. 2316
Justus Liebigs Annalen der Chemie, 1912 , vol. 389, p. 35,109
反应条件
sodium hydroxide in water T=40°C; pH=11 - 12; 3 h;
参考文献
Kawasaki, Hisashi; Koyama, Koutaro; Kurokawa, Sachio; Watanabe, Kunihiko; Nakazawa, Masakazu; Izawa, Kunisuke; Nakamatsu, Tsuyoshi
Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 1 p. 99 - 106
反应条件
1: sulfuric acid / 1 h / -10 - 5 °C / |Inert atmosphere; |Large scale 2: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 3: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 4: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
参考文献
Posner
Chemische Berichte, 1903 , vol. 36, p. 4316
Chemische Berichte, 1905 , vol. 38, p. 2316
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 25 h;
参考文献
Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950
反应条件
sodium hydrogencarbonate in water; acetone T=0°C; 3 h;
参考文献
SCHERING CORPORATION
Patent: EP1135374 B1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
0.5 h; Ambient temperature;
参考文献
Luan, Feng; Cordeiro, M. Natalia D.S.; Alonso, Nerea; Garcia-Mera, Xerardo; Caamano, Olga; Romero-Duran, Francisco J.; Yanez, Matilde; Gonzalez-Diaz, Humberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1870 - 1879
参考文献
Wu, Dongpei; Pontillo, Joseph; Ching, Brett; Hudson, Sarah; Gao, Yinghong; Fleck, Beth A.; Gogas, Kathleen; Wade, Warren S.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4224 - 4227
反应条件
tri-isobutyl aluminium in toluene T=80°C; 17 h; Yields of byproduct given;
参考文献
Tetrahedron, , vol. 49, # 8 p. 1625 - 1634
