DL-3-氨基-3-苯基丙酸合成路线 （共 124 条）
反应条件
thionyl chloride in ethanol Esterification; 5 h; Heating;
参考文献
Romanova; Rybalko; Tallo; Zyk; Svedas
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 6 p. 860 - 863
反应条件
1: 77 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 57 percent / NaHCO3 / tetrahydrofuran; H2O / 22 h / 20 °C 3: 87 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C View Scheme
参考文献
Leflemme, Nicolas; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron Letters, 2004 , vol. 45, # 7 p. 1503 - 1505
反应条件
1: sulfuric acid / 1 h / -10 - 5 °C / |Inert atmosphere; |Large scale 2: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 3: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 4: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale 5: boron trifluoride / tetrahydrofuran / 3 h / 0 - 10 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: 85 percent / 1.) HCl, 2.) NaOH 3: 98 percent / 1) 40percent aq. NaOH, 2) conc HCl / 16 h / Ambient temperature View Scheme
参考文献
Wasserman, Harry H.; Berger, Gregory D.
Tetrahedron, 1983 , vol. 39, # 15 p. 2459 - 2464
反应条件
1: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature 3: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 4: SOCl2 / Ambient temperature 5: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 6: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran 2: With methanesulfonic acid in tetrahydrofuran T=30°C; 3: With sodium hydroxide in tetrahydrofuran; water pH=9 - 10; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; JITHENDER, Aadepu; VENUGOPAL, Bingi
Patent: WO2011/161690 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature View Scheme
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
反应条件
1.1: sodium hydroxide / water / 8 h / 40 °C / pH 11 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / |Cooling with ice 2.2: 20 °C 3.1: thionyl chloride / 24 h / 20 °C 3.2: 24 h / 0 °C 4.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1.1: sodium hydroxide / water / 8 h / 40 °C / pH 11 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / |Cooling with ice 2.2: 20 °C 3.1: thionyl chloride / 24 h / 20 °C 3.2: 24 h / 0 °C 4.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
You, Pengyong; Qiu, Jian; Su, Erzheng; Wei, Dongzhi
European Journal of Organic Chemistry, 2013 , # 3 p. 557 - 565
反应条件
in sodium hydrogencarbonate; ethyl acetate; acetonitrile
参考文献
Nuevolution A/S
Patent: US2003/143561 A1, 2003 ;
