N-(2-氯乙基)吗啉盐酸盐合成路线 （共 53 条）
反应条件
potassium carbonate; xylene
参考文献
Kaye et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1421,1424
反应条件
1.1: potassium carbonate; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 100 °C 2.1: hydrogen / 5 palladium on charcoal / dimethyl sulfoxide; tetrahydrofuran; methanol / 20 °C 2.2: 60 °C 3.1: hydrogenchloride / water View Scheme
参考文献
TORAY INDUSTRIES, INC.
Patent: US2012/184735 A1, 2012 ;
参考文献
Mason; Malkiel
Journal of the American Chemical Society, 1940 , vol. 62, p. 1448
反应条件
1.1: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux 1.2: Inert atmosphere; Reflux 2.1: sodium tetrahydroborate / methanol / 20 °C View Scheme
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
1: methyl 4-hydroxy-benzoate With potassium carbonate in DMF (N,N-dimethyl-formamide) T=100°C; 2: 2-(4-morpholino)ethyl chloride hydrochloride in DMF (N,N-dimethyl-formamide) T=100°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/16611 A1, 2004 ;
Location in patent: Page 98 ;
WO 2004/016611 A1
反应条件
1: With triethylamine in N,N-dimethyl-formamide T=60 - 70°C; 2: With hydrogenchloride in water pH=2.5;
参考文献
IPCA Laboratories Ltd.
Patent: US2011/166347 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium carbonate in acetonitrile T=80°C;
参考文献
AMBIT BIOSCIENCES CORPORATION
Patent: WO2005/48948 A2, 2005 ;
Location in patent: Page/Page column 185 ;
反应条件
hydrogenchloride; n-butyllithium; potassium carbonate in tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; acetonitrile
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6492393 B1, 2002 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=160°C; 24 h;
参考文献
Fallah-Tafti, Asal; Foroumadi, Alireza; Tiwari, Rakesh; Shirazi, Amir Nasrolahi; Hangauer, David G.; Bu, Yahao; Akbarzadeh, Tahmineh; Parang, Keykavous; Shafiee, Abbas
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 4853 - 4858
反应条件
sodium hydroxide; potassium carbonate in 1-methyl-pyrrolidin-2-one T=90 - 100°C; 2 - 3 h;
参考文献
ARQULE, INC.
Patent: WO2006/10082 A1, 2006 ;
Location in patent: Page/Page column 35; 114 ;
WO 2006/010082 A1
