N-(2-氯乙基)吗啉盐酸盐合成路线 （共 53 条）
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1642880 A1, 2006 ;
Location in patent: Page/Page column 109 ;
反应条件
1: 73 percent / N methanolic KOH / ethanol / 6 h / Heating 2: 87 percent / 35 percent(m/v) hdrogen peroxide, ammonium molybdate / acetic acid; H2O / 1 h / 100 °C View Scheme
参考文献
Vittorio; Pappalardo; Ronsisvalle; Caruso; Leone; Amico-Roxas
Farmaco, 1989 , vol. 44, # 10 p. 911 - 932
反应条件
1: With potassium carbonate in water 2: With hydrazine hydrate 1 h; Reflux;
参考文献
Wolf, Barbara M.T.; Eller, Gernot A.; Holzer, Wolfgang
Heterocycles, 2008 , vol. 75, # 8 p. 2035 - 2042
反应条件
1: K2CO3 / toluene / 20 h / Heating
2: 10percent HCl / 22 h / Heating
View Scheme
参考文献
Favara; Nicola; Pappalardo; Bonardi; Luca; Marchini; Sardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 10 p. 697 - 708
反应条件
in sodium hydroxide; ethyl acetate
参考文献
Nauchno-Issledovatelsky Institut Farmakologii Rossiiskoi Akademii Meditsinskikh Nauk
Patent: US6376666 B1, 2002 ;
反应条件
1: K2CO3 / toluene / 20 h / Heating
2: 10percent HCl / 22 h / Heating
View Scheme
参考文献
Favara; Nicola; Pappalardo; Bonardi; Luca; Marchini; Sardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 10 p. 697 - 708
反应条件
caesium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide)
T=65°C; 12 h;
参考文献
Sugen, Inc.
Patent: US2004/220189 A1, 2004 ;
Location in patent: Page 37 ;
US 20040220189 A1
反应条件
sodium ethanolate in ethanol; dichloromethane
T=80°C; 1 h;
参考文献
ASTEX TECHNOLOGY LIMITED
Patent: WO2006/3440 A1, 2006 ;
Location in patent: Page/Page column 162 ;
WO 2006/003440 A1
反应条件
sodium azide in water
T=80°C;
参考文献
Xiao, Chunsheng; Cheng, Yilong; Zhang, Yu; Ding, Jianxun; He, Chaoliang; Zhuang, Xiuli; Chen, Xuesi
Journal of Polymer Science, Part A: Polymer Chemistry, 2014 , vol. 52, # 5 p. 671 - 679
反应条件
potassium carbonate in acetonitrile
T=80°C; Product distribution / selectivity;
参考文献
KINEX PHARMACEUTICALS, LLC
Patent: WO2008/82637 A1, 2008 ;
Location in patent: Page/Page column 63-64; 66 ;
