N-(2-氯乙基)吗啉盐酸盐合成路线 （共 53 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 4 h;
参考文献
STEURER, Steffen; BETZEMEIER, Bodo; MCCONNELL, Darryl; GERSTBERGER, Thomas; GRAUERT, Matthias; HOFFMANN, Matthias; IMPAGNATIELLO, Maria; van der VEEN, Lars; WEYER-CZERNILOFSKY, Ulrike
Patent: US2007/270401 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C;
参考文献
HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo
Patent: US2014/121200 A1, 2014 ;
Location in patent: Paragraph 0176; 0179; 0180 ;
反应条件
1: 2-nitro-4-hydroxy-toluene With potassium tert-butylate in tetrahydrofuran
T=20°C; 1 h;
2: 2-(4-morpholino)ethyl chloride hydrochloride With tetra-(n-butyl)ammonium iodide in tetrahydrofuran; dimethyl sulfoxide
T=95°C; 2 h;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 74 ;
WO 2007/000582 A1
反应条件
methanol; sodium methylate
1.) DMF, MeOH, 10 min, 2.) 70-80 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Li, Chuen; Sammes, Michael P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1303 - 1310
反应条件
caesium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide)
T=65°C;
参考文献
SUGEN, INC.
Patent: WO2004/76412 A2, 2004 ;
Location in patent: Page 95 ;
WO 2004/076412 A2
反应条件
potassium carbonate in acetonitrile
T=50°C;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 207-208 ;
参考文献
Bachman; Szmant
Journal of the American Chemical Society, 1946 , vol. 68, p. 31
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide
T=90 - 95°C; 5 h;
参考文献
AMBIT BIOSCIENCES CORP.; GROSS, Timothy, David; PRASAD, Achampeta, Rathan; CITINENI, Janakiram, Rao
Patent: WO2011/56939 A1, 2011 ;
Location in patent: Page/Page column 76-77 ;
反应条件
trifluoroacetic acid in N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US6090805 A1, 2000 ;
US 6090805 A
反应条件
water
Behandeln des Reaktionsgemisches mit wss. NaOH;
参考文献
Clinton et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 950,952
