1-二苯甲基-3-甲氧基-氮杂丁烷合成路线 （共 6 条）
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 2 h;
参考文献
PFIZER INC.
Patent: WO2003/106462 A1, 2003 ;
Location in patent: Page 113; 114 ;
反应条件
1: 3-amino-1-diphenylmethylazetidine With sodium hydride in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=0°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1591443 A1, 2005 ;
Location in patent: Page/Page column 68 ;
反应条件
1: 1-diphenylmethylazetidin-3-ol With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: sodium azide in N,N-dimethyl-formamide T=0 - 20°C; 1 h;
参考文献
MICURX PHARMACEUTICALS, INC.
Patent: WO2008/108988 A1, 2008 ;
Location in patent: Page/Page column 70 ;
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 25°C; 15.1667 h;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: WO2005/40151 A1, 2005 ;
Location in patent: Page/Page column 55-56 ;
WO 2005/040151 A1
反应条件
1.1: methanol / 20 - 70 °C 2.1: sodium hydride / dichloromethane; mineral oil / 0 °C / Inert atmosphere 2.2: 12 h / 20 °C / Inert atmosphere View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore
Patent: WO2012/101654 A2, 2012 ;
WO 2012/101654 A2
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr; 2 h;
参考文献
PFIZER INC.
Patent: WO2003/106462 A1, 2003 ;
Location in patent: Page 114 ;
