1-二苯甲基-3-氰基氮杂环丁烷合成路线 （共 14 条）
反应条件
lithium aluminium tetrahydride
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 1 p. 126 - 131
反应条件
in tetrahydrofuran; water
反应条件
1: With 1-chloroethyl chlorocarbonate in dichloromethane T=20°C; 3 h; 2: in methanol T=20°C; 19 h; Heating / reflux;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 49-50 ;
WO 2011/061214 A1
反应条件
1: sulfuric acid / 2 h / 90 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Morley, Andrew; Tomkinson, Nicholas; Cook, Andrew; MacDonald, Catherine; Weaver, Richard; King, Sarah; Jenkinson, Lesley; Unitt, John; McCrae, Christopher; Phillips, Tim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 20 p. 6031 - 6035
