1-(5-溴吡啶-2-基)-4-甲基哌嗪合成路线 （共 5 条）
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in toluene T=100°C; 3 h;
参考文献
Ji, Jianguo; Li, Tao; Bunnelle, William H.
Organic Letters, 2003 , vol. 5, # 24 p. 4611 - 4614
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=120°C;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; GLICK, Gary D.; TAYLOR, Clarke, Bentley; TOOGOOD, Peter, Laurence; VAN HUIS, Chad, Alan
Patent: WO2010/121164 A2, 2010 ;
Location in patent: Page/Page column 63-64 ;
反应条件
in acetonitrile 18 h; Reflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RENSLO, Adam R.; GALLARDO-GODOY, Alejandra; SILBER, B. Michael; PRUSINER, Stanley B.; GILES, Kurt; LI, Zhe; NEITZ, R. Jeffrey
Patent: WO2013/33037 A2, 2013 ;
Location in patent: Paragraph 0755 ;
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate in 1,4-dioxane T=90°C; 12 h; Inert atmosphere;
参考文献
Xuanzhu Pharma Co., Ltd.; WU, Frank; ZHANG, Yan
Patent: EP2719697 A1, 2014 ;
Location in patent: Paragraph 0169; 0172; 0173 ;
参考文献
Xuanzhu Pharma Co., Ltd.; Wu, Frank; Zhang, Yan
Patent: US2014/93505 A1, 2014 ;
Location in patent: Page/Page column ;
