4-(4-甲氧基苯基)四氢-2H-吡喃-4-甲腈合成路线 （共 4 条）
反应条件
1: (4-methoxy-phenyl)-acetonitrile With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 0.5 h;
2: 1-chloro-2-(2-chloroethoxy)ethane in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2.33333 h;
参考文献
Warner-Lambert Company LLC
Patent: EP1593679 A1, 2005 ;
Location in patent: Page/Page column 24 ;
EP 1593679 A1
反应条件
sodium hydride in 1-methyl-pyrrolidin-2-one; diethyl ether
T=0 - 20°C; 5 h;
参考文献
AMGEN INC.
Patent: WO2008/76427 A2, 2008 ;
Location in patent: Page/Page column 85 ;
反应条件
sulfuric acid; water in 1,4-dioxane
T=180°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2008/76427 A2, 2008 ;
Location in patent: Page/Page column 85-86 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 0.416667 h;
2: With sodium hydroxide; water in tetrahydrofuran
参考文献
Warner-Lambert Company LLC
Patent: EP1593679 A1, 2005 ;
Location in patent: Page/Page column 24-25 ;
EP 1593679 A1
