3-(4-溴苯基)-2-丙酸甲酯合成路线 （共 26 条）
反应条件
thionyl chloride T=0°C; 3 h; Heating / reflux;
参考文献
WO2008/23336 A2, ;
Page/Page column 91-92; 94; 96 ;
WO 2008/023336 A2
反应条件
Verkade nonionic superbase in tetrahydrofuran T=20°C; 6 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Chintareddy, Venkat Reddy; Ellern, Arkady; Verkade, John G.
Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7166 - 7174
反应条件
palladium diacetate; 1-n-butyl-3-methylimidazolium hexafluorophosphate T=20°C; Heck reaction; 3 h;
参考文献
Kabalka, George W.; Dong, Gang; Venkataiah, Bollu
Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2775 - 2777
反应条件
sodium carbonate; Pd-MCM-41 in 1-methyl-pyrrolidin-2-one T=150°C; Heck coupling; 3 h; Title compound not separated from byproducts;
参考文献
Papp, Attila; Galbacs, Gabor; Molnar, Arpad
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7725 - 7728
反应条件
in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Ikawa, Takashi; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2005 , vol. 61, # 8 p. 2217 - 2231
反应条件
in tetrahydrofuran 6 h; Heating;
参考文献
Huang, Xian; Xie, Linghong; Wu, Hong
Journal of Organic Chemistry, 1988 , vol. 53, # 20 p. 4862 - 4864
反应条件
1: diethyl methoxycarbonylmethyl-phosphonate With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: 4-bromo-benzaldehyde in tetrahydrofuran; dichloromethane T=20°C;
参考文献
Journal of the American Chemical Society, , vol. 133, # 17 p. 6642 - 6649
反应条件
in water T=90°C; Wittig reaction; 0.333333 h; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 14 p. 5244 - 5259
反应条件
1: piperidine; pyridine View Scheme
参考文献
Roczniki Chemii, , vol. 32, p. 1243,1253
Chem.Abstr., , p. 10115
反应条件
in methanol; benzene
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 10 p. 3047 - 3051
