5-(2-氨基乙基)-4-甲基咪唑合成路线 （共 6 条）
反应条件
sodium ethanolate; sodium in ethanol; dichloromethane
参考文献
Smith Kline and French Laboratories Limited
Patent: US4375435 A1, 1983 ;
反应条件
ammonia in ethanol
T=100°C; 18 h; stainless steel bomb;
参考文献
Pfister, Juerg R.; Kurz, Walter; Harrison, Ian T.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 831 - 832
反应条件
1: 60 percent
2: Br2 / methanol; butan-1-ol; dioxane / 50 - 55 °C
3: NH3 (liquid) / 1.) 24 h, 13-14 bar, 35-37 deg C, 2.) 9 h, 18-20 bar, 48-50 deg C
4: 1.) 6N NaOH, 2.) 6N HCl / 1.) water, 2 h, reflux, 2.) ethanol, reflux, 3.) water, reflux
View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
1: Br2 / methanol; butan-1-ol; dioxane / 50 - 55 °C
2: NH3 (liquid) / 1.) 24 h, 13-14 bar, 35-37 deg C, 2.) 9 h, 18-20 bar, 48-50 deg C
3: 1.) 6N NaOH, 2.) 6N HCl / 1.) water, 2 h, reflux, 2.) ethanol, reflux, 3.) water, reflux
View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
hydrogenchloride; sodium hydroxide
1.) water, 2 h, reflux, 2.) ethanol, reflux, 3.) water, reflux;
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
1: NH3 (liquid) / 1.) 24 h, 13-14 bar, 35-37 deg C, 2.) 9 h, 18-20 bar, 48-50 deg C
2: 1.) 6N NaOH, 2.) 6N HCl / 1.) water, 2 h, reflux, 2.) ethanol, reflux, 3.) water, reflux
View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
