18-crown-6 ether in diethyl ether refluxing under Ar for 5 h; cooling, evapn. of solvent, sublimating residue under vac.;
参考文献
Kampel, V.; Warshawsky, A.
Journal of Organometallic Chemistry, 1994 , vol. 469, # 1 p. 15 - 18
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反应条件
1: benzyloxycarbonyl-L-pyroglutamic acid With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=0 - 20°C; 2 h;
2: VESA-PEG-NH2 With triethylamine in tetrahydrofuran; water
T=0°C;
参考文献
Sonus Pharmaceuticals, Inc.
Patent: US6858227 B1, 2005 ;
Location in patent: Page/Page column 7-8 ;
1: alpha-tocopherol hydrogen succinate With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=0 - 20°C; 1.75 h;
2: (S)-(-)-2-pyrrolidone-5-carboxylic acid With triethylamine in tetrahydrofuran; DMF (N,N-dimethyl-formamide); water
T=0 - 20°C;
3: With hydrogenchloride in dichloromethane; water
参考文献
Sonus Pharmaceuticals, Inc.
Patent: US6858227 B1, 2005 ;
Location in patent: Page/Page column 6-7 ;
1: alpha-tocopherol hydrogen succinate With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=0 - 20°C; 1.75 h;
2: bispropylamino polyethylene glycol With triethylamine in tetrahydrofuran; water
T=0°C;
参考文献
Sonus Pharmaceuticals, Inc.
Patent: US6858227 B1, 2005 ;
Location in patent: Page/Page column 7-8 ;
