(2-对甲苯-咪唑并[1,2-a]吡啶-3-基)-乙酸合成路线 （共 6 条）
反应条件
potassium hydroxide in ethanol
8 h; Heating;
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
water; sodium hydroxide in ethanol
T=90°C; Flow reactor;
参考文献
Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V.
Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769
反应条件
1.1: 85 percent / acetic acid / H2O / 4 h / 50 - 55 °C
2.1: MeI / CH2Cl2 / 24 h / 20 °C
2.2: H2O / 4 h / Heating
3.1: 76 percent / aq. KOH / ethanol / 8 h / Heating
View Scheme
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1.1: MeI / CH2Cl2 / 24 h / 20 °C
1.2: H2O / 4 h / Heating
2.1: 76 percent / aq. KOH / ethanol / 8 h / Heating
View Scheme
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1: polymer supported sulfonic acid resin / toluene / 120 °C / |Flow reactor
2: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor
3: sodium hydroxide; water / ethanol / 90 °C / |Flow reactor
View Scheme
参考文献
Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V.
Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769
反应条件
1: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor
2: sodium hydroxide; water / ethanol / 90 °C / |Flow reactor
View Scheme
参考文献
Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V.
Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769
