3-氨基吡嗪-2-羧酸乙酯合成路线 （共 3 条）
反应条件
sulfuric acid; dihydrogen peroxide; iron(II) sulfate
1) -10 deg C, 2) 30 min, 0 deg C, 3) 30 min, room temperature;
参考文献
Vontor, Tomas; Palat, Karel; Lycka, Antonin
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 5 p. 1306 - 1310
反应条件
1.) ether, HMPT, reflux, 3 h, 2.) EtOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
1: pyridine
2: ammonia / ethanol / Heating
View Scheme
参考文献
Raboisson, Pierre; Lenz, Oliver; Lin, Tse-I; Surleraux, Dominique; Chakravarty, Sarvajit; Scholliers, Annick; Vermeiren, Katrien; Delouvroy, Frederic; Verbinnen, Thierry; Simmen, Kenneth
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1843 - 1849
